Search results for "sicilian patient"

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4843delC of the BRCA1 gene is a possible founder mutation in Southern Italy (Sicily).

2007

Various studies have been published in Italy regarding the different BRCA1 mutations, but only the BRCA1-5083del19 mutation is recurrent and specific to individuals of Italian descent with a founder effect on the Calabrian population. In our previous study, BRCA1-5083del19 mutation carriers were found in four index cases of 106 Sicilian patients selected for familial and/or hereditary breast/ovarian cancers. The high frequency rate of this mutation identified in the Sicilian population led us to perform haplotype analysis in all family carriers. Five highly polymorphic microsatellite markers were used (D17S1320, D17S932, D17S1323, D17S1326, D17S1325) to establish whether or not all these fa…

MaleBRCA1 gene Founder mutation Haplotype analysis Hereditary breast and ovarian cancer Sicilian patientsSettore MED/06 - Oncologia MedicaGenetic counselingPopulationDNA Mutational AnalysisGenes BRCA1Single-nucleotide polymorphismBreast NeoplasmsBiologyBRCA1 geneHaplotype analysiHumansAlleleeducationAllelotypeFounder mutationSicilyGeneticsOvarian Neoplasmseducation.field_of_studyHaplotypeHematologylanguage.human_languageFounder EffectPedigreeOncologyHaplotypesHaplotype frequencylanguageFemaleSicilianGene DeletionFounder effectGenetic counselingMicrosatellite Repeats
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Significance of persistence of antibodies against Leishmania infantum in Sicilian patients affected by acute visceral leishmaniasis.

2012

The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibodies observed in 2 cases of VL relapse and 2 cases of resistance to therapy. The methods which we used to obtain our objective are the following: 55 apparently immunocompetent, HIV-negative patients were examined for antibodies to L. infantum by IFAT over 14 years period, and we got the following results: Serum-specific IgG antibodies titers decrease slowly, but constantly. In t…

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaTime FactorsAdolescentsicilian patientacute visceral leishmaniasisAntibodies ProtozoanFluorescent Antibody TechniqueGeneral Biochemistry Genetics and Molecular BiologyPersistence (computer science)Young AdultRecurrenceInternal medicineparasitic diseasesMedicineHumansYoung adultLeishmania infantumantibodies; Leishmania infantum; sicilian patients; acute visceral leishmaniasisSicilyAgedAged 80 and overHematologybiologybusiness.industryLeishmaniasisGeneral MedicineMiddle Agedmedicine.diseasebiology.organism_classificationVirologyTiterVisceral leishmaniasisantibodieImmunoglobulin GImmunologybiology.proteinLeishmaniasis VisceralFemaleAntibodyLeishmania infantumbusinessClinical and experimental medicine
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A non common BRAF mutation c1799-1801 delTGA identified in sporadic colon rectal cancer of sicilian patients

2010

Anthracycline has been shown to induce heart failure. To monitor this toxic damage, echocardiographic parameters of left ventricular (LV) systolic function are usually used. Aim of this study was to evaluate in lymphoma’s patients the reliability of echocardiographic data in comparison with a LV systo-diastolic parameter function: the Tei index.

BRAF mutation sicilian patients
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